Origins of Human Cancers
نویسندگان
چکیده
منابع مشابه
TP53 mutations in human cancers: origins, consequences, and clinical use.
Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which predisposes to a wide spectrum of early-onset cancers. Most mutations are single-base substitutions distributed throughout the coding sequence. Their diverse types and positions may inform on the nature of mutagenic mechanis...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1985
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262338501300204